Seronegative Arthritis Emedecine

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Facts From Seronegative Arthritis Emedecine

Seronegative arthritis constitutes a broad spectrum of diseases of unknown origin. Food antigens have been suggested to be involved in few selected cases of seronegative arthritis. Seronegative arthritis can at times be symmetric, that is affecting joints on both sides of the body. There is a range of seronegative arthritis diseases with possible systemic manifestations including the main procedures for early diagnosis. Infection, malignancy, hypersensitivity, granulomatous disease and other collagen diseases such as systemic lupus erythematosus should be excluded, but investigations for an underlying disease should not delay early corticosteroid and immunosuppressive therapy.

Data from various studies suggest that nickel sulphate, an ubiquitous metal, can induce an exacerbation of arthralgias in patients with previous sensitization to nickel itself. Contact with nickel may occur not only through the skin but also through gastrointestinal mucosa, by the ingestion of certain food items.

The most destructive type of seronegative arthritis is arthritis mutilans, which is usually quite severe to the point of being deforming. Only a small percentage of people are ever affected with this type. Since all of these types are the result of inflammation, treatment involves controlling, or where possible reducing, inflammation.

One group within the umbrella of seronegative arthritis types is referred to as reactive arthritis. In these cases, the arthritis appears to result form some other disorder in the body, and the symptoms often seem unrelated and therefore difficult to diagnose. In its most commonly experienced form, reactive arthritis involves the urinary tract, the eyes, and the skin as well as joints. All the common forms of arthritis, including rheumatoid and seronegative arthritis, affect the feet and can cause chronic foot pain.

While rheumatoid arthritis affects primarily the joints, seronegative arthritis has a number of different, and sometimes seemingly unrelated symptoms. With only an occasional exception, seronegative arthritis affects only males. There also appears to be a strong genetic link involved as seronegative arthritis has a tendency to run in families. Unlike rheumatoid arthritis, seronegative arthritis often affects more than just the joints, extending to inflammation of tendon attach points, and often damaging cartilage. Symptoms of seronegative arthritis can also be observed in the skin as psoriasis, the eyes and the bowels. The larger joints, often just a single joint, tend to be affected more than many smaller joints.

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